Differential pressure sensors ensure sterile containment through accurate and stable pressure management between clean and adjacent rooms.
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Differential pressure measurement

 

Differential pressure sensors ensure sterile containment through accurate and stable pressure management between clean and adjacent rooms.

Description

Huba Control’s range, with leading models such as the 699 and 610, employs highly sensitive ceramic cantilever beam technology. These transducers offer exceptional accuracy even at very low pressure ranges, ensuring that the air gradient always protects critical areas from contaminants.

In addition, the capacitive sensor technology offered by sensors such as VAISALA’s PDT101 ensures superior thermal stability and millimeter accuracy in low ranges, facilitating compliance with stringent regulations through seamless integration.

The importance of pressure and the Huba Control solution

In cleanroom design, differential pressure is the parameter that acts as an invisible physical barrier. Its function is to create a directed air flow from the cleanest to the least clean areas (pressure cascade), preventing particles or pathogens from entering the critical points of pharmaceutical manufacturing.

Huba Control, the Swiss specialist in pressure technology, offers solutions designed for this application:

  • Low range accuracy: Able to accurately measure minute variations (from 0 to 25 Pa), essential to maintain HVAC system balance without excessive energy consumption.
  • Long-term stability: Thanks to its ceramic sensing element, the equipment does not suffer significant time drifts, reducing the frequency of recalibration and ensuring successful audits.
  • Output versatility: Its equipment allows analog or digital (Modbus) outputs for direct integration into the room’s PLC or centralized monitoring system.
  • Maintaining a controlled differential pressure with high-end sensors is not only a legal requirement of ISO 14644 standards, but the only guarantee that product integrity will not be compromised by untreated air infiltration.
Precision and stability with Vaisala

In life sciences, differential pressure is the gatekeeper of sterility. Vaisala sensors are specifically developed to eliminate measurement errors caused by drift or ambient temperature changes, common problems in lower quality sensors.

– Capacitive Sensor Technology: Unlike other methods, Vaisala’s technology offers minimal hysteresis and immediate recovery after overpressures, ensuring that the cleanroom air cascade is always kept within safe limits.

– Critical Installation Design: The PDT101 model is extremely compact, allowing for DIN rail or direct panel mounting. It includes factory traceable calibration certificates, a must for IQ/OQ validation processes.

– Advanced Digital Monitoring: By natively integrating with the viewLinc system, Vaisala pressure sensors allow historical trends to be viewed and intelligent alerts to be set up. This ensures that any fluctuations in airflow are automatically detected and recorded for the audit trail.

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More information about Differential pressure measurement

Why is thermal validation important?

  • Regulatory compliance: demonstrates compliance with applicable regulations, good manufacturing practices and relevant standards, and provides evidence for regulatory submissions and inspections.
  • Reliable performance and product launch: demonstrates that the process is reproducible and supports sound launch decisions.
  • Quality assurance and product integrity: guarantees microbiological safety while protecting the material, functional and stability properties throughout the product life cycle.
  • Risk mitigation: reduces the likelihood of recalls, deviations, adverse events and costly corrective actions.
  • Audit readiness and data integrity: creates traceable and well-documented records (including raw data and metadata) required for audits and inspections.
  • Life cycle control: defines change control triggers, revalidation criteria and periodic requalification to maintain long-term compliance.
  • Business and reputation protection: helps avoid financial losses and preserves customer and stakeholder confidence.